Rabbit Secondary Antibodies
Cayman Chemical PSD95NTerm RabbIt Moncl 100uL
An isomer of vitamin D3 increases tibia ash weight and bone mineralization in vitamin D-deficient chicks at 1 3 and 10 Ug/day induces intestinal calcium transport and bone calcium mobilization in anephric rats fed a low-calcium and vitamin D-deficient diet at 25 Ug/animal
ABclonal Technology TAP2 Rabbit mAb
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ABC proteins transport various molecules across extra- and intra-cellular membranes ABC genes are divided into seven distinct subfamilies (ABC1 MDR TAP MRP ALD OABP GCN20 White) This protein is a member of the MDR TAP subfamily Members of the MDR TAP subfamily are involved in multidrug resistance This gene is located 7 kb telomeric to gene family member ABCB2 The protein encoded by this gene is involved in antigen presentation This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum Mutations in this gene may be associated with ankylosing spondylitis insulin-dependent diabetes mellitus and celiac disease Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules
Cayman Chemical CD3εCTerm RabbIt Monclon 100uL
An inhibitor of B-RAF and C-RAF (IC50s 41 7 and 2 nM for wild-type B-RAF B-RAFV600E and wild-type C-RAF respectively) cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s 57 and 69 nM respectively) as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62 thyroid cancer cells (IC50s 116 65 43 and 479 nM respectively) reduces tumor growth in A375 SK-MEL-28 SK-MEL-2 and SK-MEL-30 mouse xenograft models
ABclonal Technology OTC Rabbit mAb
This nuclear gene encodes a mitochondrial matrix enzyme The encoded protein is involved in the urea cycle which functions to detoxify ammonia into urea for excretion Mutations in this enzyme lead to ornithine transcarbamylase deficiency which causes hyperammonemia
ABclonal Technology SMPD3/NSMase2 Rabbit mAb
Predicted to enable phosphatidic acid binding activity phosphatidylserine binding activity and sphingomyelin phosphodiesterase activity Predicted to be involved in positive regulation of exosomal secretion and sphingomyelin metabolic process Predicted to act upstream of or within several processes including animal organ development enzyme linked receptor protein signaling pathway and sphingolipid metabolic process Predicted to be located in Golgi apparatus and plasma membrane Predicted to be active in cytoplasm Biomarker of pulmonary emphysema
ABclonal Technology PSMC5 Rabbit mAb
The 26S proteasome is a multicatalytic complex composed of a 20S core and a 19S regulator The 20S core has four rings of 28 subunits (two rings of 7 alpha and two of 7 beta subunits) The 19S regulator includes a base (6 ATPase and 2 non-ATPase subunits) and a lid (up to 10 non-ATPase subunits) Proteasomes abundant in eukaryotic cells degrade peptides in an ATP- and ubiquitin-dependent manner outside of lysosomes The immunoproteasome variant processes MHC class I peptides This gene encodes one of the ATPase subunits part of the AAA family of ATPases with chaperone-like activity Beyond proteasome function this subunit may regulate transcription by interacting with thyroid hormone and retinoid X receptors Two transcript variants encoding different isoforms exist
ABclonal Technology AUH Rabbit mAb
This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA a critical step in the leucine degradation pathway This protein also binds AU-rich elements (AREs) found in the 3 UTRs of rapidly decaying mRNAs including c-fos c-myc and granulocyte macrophage colony stimulating factor ARE elements are involved in directing RNA to rapid degradation and deadenylation This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis Mutations in this gene are the cause of 3-methylglutaconic aciduria type I Alternative splicing results in multiple transcript variants
Cayman Chemical InTRleukIn18 RabbIt Monclo 1mL
Immunogen: Recombinant human IL-18 • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) IL-18 • Applications: ELISA, ELISA (CAP)
ABclonal Technology 647 Rabbit anti- CD205/DEC-205
Predicted to enable signaling receptor activity Predicted to act upstream of or within endocytosis Located in external side of plasma membrane Is expressed in thymus and thymus primordium Orthologous to several human genes including LY75-CD302 (LY75-CD302 readthrough)
ABclonal Technology Villin1 Rabbit mAb
This gene encodes a member of a family of calcium-regulated actin-binding proteins This protein represents a dominant part of the brush border cytoskeleton which functions in the capping severing and bundling of actin filaments Two mRNAs of 2 7 kb and 3 5 kb have been observed they result from utilization of alternate poly-adenylation signals present in the terminal exon
ABclonal Technology Puromycin Rabbit mAb
Puromycin is an aminonucleoside antibiotic derived from the Streptomyces alboniger bacterium that causes premature chain termination during translation taking place in the ribosome It has a role as a nucleoside antibiotic an antiinfective agent an antineoplastic agent a protein synthesis inhibitor an antimicrobial agent an EC 3 4 11 14 (cytosol alanyl aminopeptidase) inhibitor and an EC 3 4 14 2 (dipeptidyl-peptidase II) inhibitor It is a conjugate base of a puromycin(1 ) Puromycin is an antibiotic that prevents bacterial protein translation It is utilized as a selective agent in laboratory cell cultures Puromycin is toxic to both prokaryotic and eukaryotic cells resulting in significant cell death at appropriate doses
ABclonal Technology eIF1A Rabbit mAb
This gene encodes an essential eukaryotic translation initiation factor The protein is required for the binding of the 43S complex (a 40S subunit eIF2 GTP Met-tRNAi and eIF3) to the 5 end of capped RNA
ABclonal Technology BTN2A1 Rabbit mAb
This gene encodes a member of the immunoglobulin superfamily The gene is located in a cluster of butyrophilin-like genes in the juxta-telomeric region of the major histocompatibility complex on chromosome 6 A pseudogene of this gene has been identified in this cluster The encoded protein is an integral plasma membrane protein involved in lipid fatty-acid and sterol metabolism Alterations in this gene may be associated with several disease states including metabolic syndrome Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene